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KMID : 0545120080180111848
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Journal of Microbiology and Biotechnology
2008 Volume.18 No. 11 p.1848 ~ p.1852
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In Vitro Activity of Methyl Gallate Isolated from Galla Rhois Alone and in Combination with Ciprofloxacin Against Clinical Isolates of Salmonella
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Choi Jang-Gi
Kang Ok-Hwa
Lee Young-Seob
Oh You-Chang
Chae Hee-Sung
Jang Hye-Jin
Kim Jong-Hak
Sohn Dong-Hwan
Shin Dong-Won
Park Hyun
Kwon Dong-Yeul
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Abstract
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Salmonella remains a primary cause of food poisoning worldwide, and massive outbreaks have been witnessed in recent years. Therefore, this study investigated the antimicrobial activity of methyl gallate (MG), which exhibited good antibacterial activity (MIC=3.9-125 mg/ml) against all the bacterial strains tested. In a checkerboard dilution test, MG markedly lowered the MICs of ciprofloxacin (CPFX) against Salmonella. The combined activity of CPFX and MG against Salmonella resulted in fractional inhibitory concentrations (FICs) ranging from 0.0037 to 0.015 and from 0.24 to 7.8 mg/ml, respectively. Meanwhile, the FIC index ranged from 0.31-0.37, indicating a marked synergistic relationship between CPFX and MG against Salmonella. Time-kill assays also showed a decrease in the CFU/ml between the combination and the more active compound. Therefore, this study demonstrated that MG and CPFX can act synergistically in inhibiting Salmonella in vitro.
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KEYWORD
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Salmonella, ciprofloxacin, methyl gallate, synergism
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